I agree with RProffer and Starr. I would much rather tow a heavy load on the interstate, as long as you aren't going to be stuck in stop-and-go (which I know 95 suffers from time to time). Better services, truck stops and other places to pull off with a large load when needed, better grades, fewer sharp turns/blind corners/35 MPH zones, etc.
Certainly a lesser highway would be more scenic, but also many more chances for bad things to happen. Lots of parking lots for people to suddenly turn onto the highway in front of you, lots of slower speed zones and stoplights as you go through populated areas, narrower lanes, more chances of a deer running out.