Jim,
The coolant is good for 5 years or 100,000 miles so Chevy says. We had our antifreeze changed because of the age of it before our last trip. Our truck had the transmission fluid changed along with a filter and the transfer case and both differentials oil changed at 50,000 miles.
I do the engine oil changes so I never end up having to do it while in the middle of a trip. If we have 8000 miles on the oil and a 3000 mile trip planned I do the oil before we head out. Amsoil does not recommend using synthetic oil to extend oil change intervals in Duramax engines. I change the fuel filter every oil change no matter what the computer says which is always well in advance of the suggested interval.
I plan on switching to Amsoil transmission fluid as its been reported to drop the transmission oil temperature by 25% as reported by an actual end user truck owner. I'll will do the differentials and transfer case again at a 100,000 miles as I believe doing oil changes on differentials and transfer case every 50,000 is cheap insurance. Using four drive or not the differentials still spin. On our last trip we did have an issue. It seems that the intercooler which sits in front of the radiator has larger gaps in between the fins than the radiator. So debris gets through the intercooler and then packs up in the radiator fins. We had the radiator and intercooler pulled out and pressure washed as our temperature was running higher than normal on long hard pulls. The build up is heavier that is right in front of where the fan is located. Something you and other diesel brand owners should keep in mind. In our travels people also stressed to not run these trucks low on fuel. The pumps are lubed by the diesel fuel and are after the fuel filters. Without the lubrication from the diesel fuel during the fuel sloshing around causing the pump to run dry can cause particulates to foul an injector. Plus the fuel pump is buried in the engine and is expensive to replace. This was reported to true for most brands.